• Through the analysis of various synthetic GPR agonists

  2022-05-27

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic dexamethasone acetate motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of di

• Free fatty acids FFAs which are obtained from

  2022-05-27

  

  Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty Epiberberine receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Short

• Hyperactivation of Notch pathway can give rise to

  2022-05-27

  

  Hyperactivation of Notch1 pathway can give rise to transformation into T-ALL in murine models. In more than 50% of acute T-cell lymphoblastic leukemias oncogenic activating mutations of Notch1 have been detected and inactivation of Notch1 signaling impairs leukemia cell proliferation and promotes ap

• In the Joint United Nations Program on HIV AIDS

  2022-05-27

  

  In 2015, the Joint United Nations Program on HIV/AIDS (UNAIDS) proposed that by 2020, 90% of people living with HIV should be aware of their HIV status, as the first part of 90-90-90 strategy to end AIDS epidemic. Early detection of HIV allows initiating care for proper treatment, which impacts in m

• br Conflict of interest br Acknowledgments We

  2022-05-27

  

  Conflict of interest Acknowledgments We thank Professor Chen Rui (Southeast University, China) for providing plasmid P1P2N-HIF1. This study was supported by research grants from National Natural Science Foundation of China (81573189, 81730087). Introduction The consumption of large amounts

• Introduction Hedgehog HH signaling regulates development cel

  2022-05-27

  

  Introduction Hedgehog (HH) signaling regulates development, cell proliferation, and tissue repair [1], [2], [3]. In mammals, HH signaling is activated by 3 ligands: Sonic hedgehog (SHH), Indian hedgehog (IHH), or Desert hedgehog; SHH is the most widely expressed in adult tissues [3]. The primary re

• NCSs are helical proteins containing four EF

  2022-05-27

  

  NCSs are α-helical proteins containing four EF-hand motifs with EF1 being incapable of Ca-binding throughout the family (atomic-resolution structure was firstly resolved for recoverin [5]; for review on NCS structure, see [6]). Some of the NCS proteins (i.e. recoverin and KChIP3) have two while othe

• We have shown previously that

  2022-05-27

  

  We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates HOBt cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-genomic TGFβ-induced cell respo

• Decreased ratio of Treg TH is reported to

  2022-05-27

  

  Decreased ratio of Treg/TH17 is reported to correlate with MS disease severity [63]. Treg Fmoc-Val-OH are the major anti-inflammatory subset of T cells which suppress proinflammatory T-cells by producing anti-inflammatory cytokines, such as IL-10 and TGF-β, as well as play a critical role in maintai

• To date no studies have demonstrated any effect

  2022-05-27

  

  To date, no studies have demonstrated any effect of obesity or inflammation on GPR109A expression in adipose tissue. Our findings demonstrate that HFD-induced obesity decreases adipose tissue GPR109A gene expression. Contradictory to our findings in adipose tissue in vivo, Digby et al. report that e

• 49 9 br Surrogate ligands for GPR Although

  2022-05-26

  

  Surrogate ligands for GPR35 Although identification of endogenously produced chemicals with agonist action at GPR35 is of considerable importance, the ligands described above are far from ideal to probe the roles of GPR35. Surrogate ligands are therefore required. Until recently, the key GPR35 ag

• Treatment with probiotics can also be used

  2022-05-26

  

  Treatment with probiotics can also be used to alter the microbiota profile of CF patients. One study reports that administration of the probiotic Lactobacillus Reuteri improved digestive health and inflammation [112]. The fecal microbial profile changed, showing a decrease in Proteobacteria and an i

• br Acknowledgements We thank the support of the National Nat

  2022-05-26

  

  Acknowledgements We thank the support of the National Natural Science Foundation of China (NSFC) project 81501342 and support from the Disciplinary Group of Oncology and Immunology program of Xinxiang Medical University. Introduction First described as a new clinical entity in 1981, the Acqui

• To further investigate if GPR was the functional target of

  2022-05-26

  

  To further investigate if GPR40 was the functional target of these phenylpropiolic Nitidine chloride analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. HEK2

• Several studies have found decreased astroglial and

  2022-05-26

  

  Several studies have found decreased astroglial and neuronal cell numbers and risedronic acid damage after OP exposure. Neuronal loss and brain lesions increase proportionally to the severity and duration of OP-induced seizures (Albuquerque et al., 2006, Carpentier et al., 2000, Gullapalli et al., 2

15608 records 416/1041 page Previous Next First page 上5页 416417418419420 下5页 Last page